Anaphylaxis V2 Case Definition

This is a revision of the Brighton Collaboration Case Definition of the term “Anaphylaxis” to be utilized in the evaluation of adverse events following immunization. The case definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) as part of the Safety Platform for Emergency vACcines (SPEAC) project, in the context of active development of vaccines for COVID-19 and other emerging pathogens. The case definition format of the Brighton Collaboration was followed to develop a consensus case definition and defined levels of diagnostic certainty, after an exhaustive review of the literature and expert consultation. 

The revised Brighton Case Definition for Anaphylaxis was submitted to Vaccine on October 17th, 2022. 

Click here to download the submitted revised Brighton Case Definition of Anaphylaxis

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