COVID-19

Relevant Brighton Collaboration Resources and Tools

Brighton Collaboration is working diligently to fight the coronavirus disease (COVID-19) pandemic.

The Brighton Collaboration (BC) Safety Platform for Emergency vACcines project is creating resources and tools to facilitate COVID-19 vaccine safety clinical trials and pharmacovigilance. Each is described briefly below, along with a link to the specific content page for all AESI. Further information regarding availability for each AESI is provided at the content page.

To view a complete list of Brighton Collaboration (BC) publications and related tools, please click herePublications and related tools are organized in a Google spreadsheet that is sortable and filterable by each column. Direct clickable links to publication DOIs are provided.

New BC publications and related tools relevant to COVID-19 will also be posted on our Publications and Related Tools page as they become available.

 

BC Resources and Tools Relevant for COVID-19:

 

COVID AESI List: Literature review and quarterly updates

Documents that describe the methods, including search terms and references used to develop the May 2020 AESI list and quarterly updates (Sep&Dec2020, Mar&Jun2021).

Excel spreadsheet with updated citations, tabbed by AESI

 

Webinars

Webinars to explain and discuss relevant BC work.

BRAVATO templates

1.      Already published BC templates

2.      Draft BC templates

AESI Case Definitions

1.      Already published BC Case definitions

2.      Draft BC Case definitions

AESI Data abstraction & Interpretation Forms

Detailed case report forms for collection of clinical and laboratory case data from hospital or other collections of medical data with instructions for applying the data to determine Brighton case definition level of diagnostic certainty.  These also summarize what data are needed to meet the case definition. 

AESI 1 page Tabular Checklists

One page data summary forms based on key Brighton case definition criteria needed for level of certainty assessment.

AESI 1 page pictorial algorithms

Pictorial stepwise guide (decision tree) to assign case definition level of certainty. 

AESI LOC online tool

Questionnaire based guide to assign level of certainty (LOC). [Under development: expected by early 2021]

AESI Background rates

Presentation of AESI population-based incidence (overall and by country,  gender and age where known) based on published literature and new studies done specifically for COVID-19. [Under development: expected by early 2021]

AESI Risk Factors

Tabular presentations of known AESI risk factors and/or causes.

AESI ICD9/MedDRA codes

Tabular presentations of ICD and MedDRA codes that can be used to search for and/or code AESI in research and pharmacovigilance databases as well as for administrative databases.

Glossary of terms

Glossaries to define terms used in the anaphylaxis and neurologic case definitions.

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