Interim Case Definition of Thrombosis with Thrombocytopenia Syndrome (TTS)

Since February, 2021, multiple countries have reported cases of Thrombosis with Thrombocytopenia Syndrome (TTS) in persons who received the COVID-19 vaccine. To further our understanding of a possible association of cases observed with thrombocytopenia and thrombosis following receipt of COVID-19 vaccines, Brighton Collaboration has developed the following interim case definition. The purpose of this interim case definition is to identify individuals that could then be studied using a common study protocol and assessment. 

Click here to view the current interim case definition v9.2.

Patients and health care professionals meeting this definition should report to their respective competent health authorities if they have not already. (e.g., for the EU, and the US).

We are compiling a draft master list of questions for the follow-up study of TTS patients here based on available questionnaires.

Please review and provide suggestions/comments for additional questions to be included using this google form.  

If you have any comments on the interim case definition, please submit them here.  Note that unless there is a strong reason to do so, we’ll postpone incorporating them until development of the final case definition.

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